The catalase—peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis

Isoniazid MIC and KatG Gene Mutations among Mycobacterium tuberculosis Isolates in Northwest of Iran

Objective(s) Isoniazid (INH) is one of the main first line drugs used in treatment of tuberculosis and development of resistance against this compound can result in serious problems in treatment procedures. Resistance to INH is mediated mainly by mutation in KatG gene that is coded for the catalase enzyme. The proportional method for detection of INH-resistance is time consuming due to the slo...

The molecular basis of isoniazid resistance in Mycobacterium tuberculosis.

Isoniazid, the hydrazide of isonicotinic acid, was synthesized for the first time in 1912 by two Czech scientists, but its powerful antituberculous activity was detected only in 1951, and the discovery of isoniazid was a milestone in the chemotherapy of tuberculosis. Its activity is excellent against species of the Mycobacterium tuberculosis complex (M. tuberculosis, Mycobacterium bovis, Mycoba...

Resistance to rifampicin and isoniazid in strains of Mycobacterium tuberculosis.

Drug susceptibility studies on strains of Mycobacterium tuberculosis isolated from widely different populations of patients and tested by two different techniques indicated that all 55 strains resistant to rifampicin were also resistant to isoniazid, while many strains resistant to isoniazid were found to be susceptible to rifampicin. This observation, which has as yet unknown laboratory and cl...

Isoniazid resistance and the point mutation of codon 463 of katG gene of Mycobacterium tuberculosis.

It has long been known that almost all isoniazid (INH) resistant mycobacteria lose the catalase and peroxidase activities along with reduced or no virulence for guinea pigs. Recently resistance to INH has become known to be associated with mutations of katG gene encoding the HPI (Hydroperoxidase I) type catalase and peroxidase. Among these mutations, the point mutation of codon 463 of katG gene...

Minor Contribution of inhA-15 Mutations to the Rapid Detection of Isoniazid Resistance in Mycobacterium Tuberculosis Isolates